Endocrine Abstracts

Child obesity is a major public health concern in England and worldwide. It is a risk factor for the onset of type 2 diabetes and other comorbidities. Young people from the most deprived communities, from ethnic minority backgrounds or with learning disabilities are particularly at risk. NHS England funded the establishment of Complications of Excess Weight (CEW) pilot clinics, two of which serve the Midlands region. These provide specialist multidisciplinary whole-family supp...

Changes in glycan composition are common in cancer and can play important roles in all of the recognised hallmarks of cancer (1). We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly up-regulated in prostate cancer tissue (4). These 8 enzymes are under direct control of the and...